Columbus, fornavn engelsk af Christopher Columbus, som forekommer i adskillige toponymer
Amerikas Forenede Stater
- Columbus, hovedstad iOhio
- Columbus, amtssædet i Polk County, North Carolina
- Columbus, en by i Burke County, North Dakota
- Columbus, amtssædet for Muscogee County, Georgien
- Columbus, Landsbyen Adams County, Illinois
- Columbus, amtssæde i Bartholomew County, Indiana
- Columbus, amtssædet i Cherokee County, Kansas
- Columbus, en by i Hickman County, Kentucky
- Columbus, By i Light County, Michigan
- Columbus, et township i St. Clair County, Michigan
- Columbus, by i Anoka County, Minnesota
- Columbus, amtssædet i Lowndes County, Mississippi
- Columbus, By Missouri
- Columbus, amtssædet for Stillwater County, Montana
- Columbus, hovedstad i Platte County, Nebraska
- Columbus, en by i Chenango County, New York
- Columbus, landsby Luna County, Ny mexico
- Columbus, Warren County Township, Pennsylvania
- Columbus, amtssædet i Colorado County, Texas
- Columbus, en by i Columbia County og Dodge County, Wisconsin